Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 18 Researches
7.4
USERS' SCORE
Moderately Good
Based on 35 Reviews
7.8
Supplement Facts
Serving Size: 2 Veg Capsules
Amount Per Serving
%DV
Saccharomyces boulardii (10 Billion CFU)(Saccharomyces cerevisiae var. boulardii I-3799)
1,000 mg
**
Top Medical Research Studies
9.5
We explored how Saccharomyces cerevisiae affects patients with irritable bowel syndrome (IBS). In a study involving thirty participants, we administered 500 mg capsules of this yeast twice daily for four weeks. Weekly evaluations showed significant improvements in abdominal pain and general quality of life, with notable reductions in pain scores and enhancements in various aspects of daily living. This suggests Saccharomyces cerevisiae could be a valuable treatment option for alleviating IBS symptoms.
9
We conducted a study to assess the effectiveness of Saccharomyces cerevisiae CNCM I-3856 in treating irritable bowel syndrome (IBS). Using a randomized, placebo-controlled design, 100 newly diagnosed IBS patients received either the yeast or a placebo alongside standard treatment for 8 weeks.
We found significant reductions in abdominal pain and improved stool consistency in patients taking S. cerevisiae compared to the placebo group. All subgroups, including IBS-D, IBS-C, and IBS-M, showed notable benefits without serious adverse events.
Our findings suggest that S. cerevisiae can be a promising add-on therapy for IBS relief.
We found significant reductions in abdominal pain and improved stool consistency in patients taking S. cerevisiae compared to the placebo group. All subgroups, including IBS-D, IBS-C, and IBS-M, showed notable benefits without serious adverse events.
Our findings suggest that S. cerevisiae can be a promising add-on therapy for IBS relief.
8
We explored the impact of the probiotic I-3856 on managing irritable bowel syndrome with predominant constipation (IBS-C) through a thorough eight-week randomized, double-blind study involving 456 participants.
The findings showed that 45.1% of those taking I-3856 reported significant relief from abdominal pain compared to 33.9% in the placebo group. While I-3856 improved quality of life scores, the study did not demonstrate significant changes in bowel movement frequency.
Overall, I-3856 shows promise in alleviating abdominal pain and enhancing quality of life for those suffering from IBS-C.
The findings showed that 45.1% of those taking I-3856 reported significant relief from abdominal pain compared to 33.9% in the placebo group. While I-3856 improved quality of life scores, the study did not demonstrate significant changes in bowel movement frequency.
Overall, I-3856 shows promise in alleviating abdominal pain and enhancing quality of life for those suffering from IBS-C.
Most Useful Reviews
9
Quick bowel relief
6 people found this helpful
This remedy effectively tackled bowel issues, especially post-antibiotic use, and produced results almost immediately after the first capsule. My husband's digestive troubles have significantly improved; he now asks for them whenever he feels discomfort. Highly recommended!
9
Effective for IBS
4 people found this helpful
This is the first time I've purchased this product, recommended by a friend for my irritable bowel syndrome and gastritis. My husband and I take 2 capsules daily before meals, and it has worked remarkably well. He no longer experiences sudden diarrhoea and his bowel movements are normal. I am pleased and would love to purchase again in the future. Highly recommended!
9
Tremendous relief experienced
2 people found this helpful
After a bout of C-diff, my doctor recommended this probiotic. It helped enormously; I have continued taking it, and anyone with bowel issues should give it a try.
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 18 Researches
7.4
- All Researches
9.5
We explored how Saccharomyces cerevisiae affects patients with irritable bowel syndrome (IBS). In a study involving thirty participants, we administered 500 mg capsules of this yeast twice daily for four weeks. Weekly evaluations showed significant improvements in abdominal pain and general quality of life, with notable reductions in pain scores and enhancements in various aspects of daily living. This suggests Saccharomyces cerevisiae could be a valuable treatment option for alleviating IBS symptoms.
9
We explored how Saccharomyces boulardii CNCM I-745 influences gastrointestinal issues related to irritable bowel syndrome (IBS) using a mouse model. By inoculating mice with Herpes Simplex Virus type 1 to simulate IBS symptoms, we found that the probiotic improved gut motility and reduced inflammation. After four weeks of treatment, the probiotic not only enhanced intestinal movement but also restored nerve structure integrity and decreased harmful cytokine levels. Overall, Saccharomyces boulardii shows promise in addressing IBS-like symptoms in our animal study.
9
We investigated how saccharomyces cerevisiae affects gut motility in rats undergoing repeated water avoidance stress, simulating diarrhea-predominant irritable bowel syndrome.
The study revealed that treatment with saccharomyces cerevisiae significantly reduced excessive defecation and colonic hypermotility. We noted improvements in the contractile activity of colonic muscles, along with changes in immune responses and gut microbiota diversity.
Overall, saccharomyces cerevisiae showed promise for alleviating symptoms associated with IBS-D by addressing both gut motility and inflammation.
The study revealed that treatment with saccharomyces cerevisiae significantly reduced excessive defecation and colonic hypermotility. We noted improvements in the contractile activity of colonic muscles, along with changes in immune responses and gut microbiota diversity.
Overall, saccharomyces cerevisiae showed promise for alleviating symptoms associated with IBS-D by addressing both gut motility and inflammation.
9
We conducted a study to assess the effectiveness of Saccharomyces cerevisiae CNCM I-3856 in treating irritable bowel syndrome (IBS). Using a randomized, placebo-controlled design, 100 newly diagnosed IBS patients received either the yeast or a placebo alongside standard treatment for 8 weeks.
We found significant reductions in abdominal pain and improved stool consistency in patients taking S. cerevisiae compared to the placebo group. All subgroups, including IBS-D, IBS-C, and IBS-M, showed notable benefits without serious adverse events.
Our findings suggest that S. cerevisiae can be a promising add-on therapy for IBS relief.
We found significant reductions in abdominal pain and improved stool consistency in patients taking S. cerevisiae compared to the placebo group. All subgroups, including IBS-D, IBS-C, and IBS-M, showed notable benefits without serious adverse events.
Our findings suggest that S. cerevisiae can be a promising add-on therapy for IBS relief.
8
We explored how Saccharomyces boulardii CNCM I-745 impacts intestinal motility, particularly in the context of irritable bowel syndrome (IBS) with diarrhea. Using isolated rat ileum, we observed that S. boulardii can significantly reduce contractions induced by serotonin, suggesting it helps to regulate bowel movements.
This probiotic appears to work by inhibiting serotonin-induced contractions, providing insight into its potential effectiveness for those suffering from IBS. However, it didn’t influence contractions caused by acetylcholine, indicating a targeted action on serotonin pathways.
This probiotic appears to work by inhibiting serotonin-induced contractions, providing insight into its potential effectiveness for those suffering from IBS. However, it didn’t influence contractions caused by acetylcholine, indicating a targeted action on serotonin pathways.
User Reviews
USERS' SCORE
Moderately Good
Based on 35 Reviews
7.8
- All Reviews
- Positive Reviews
- Negative Reviews
9
Quick bowel relief
6 people found this helpful
This remedy effectively tackled bowel issues, especially post-antibiotic use, and produced results almost immediately after the first capsule. My husband's digestive troubles have significantly improved; he now asks for them whenever he feels discomfort. Highly recommended!
9
Effective for IBS
4 people found this helpful
This is the first time I've purchased this product, recommended by a friend for my irritable bowel syndrome and gastritis. My husband and I take 2 capsules daily before meals, and it has worked remarkably well. He no longer experiences sudden diarrhoea and his bowel movements are normal. I am pleased and would love to purchase again in the future. Highly recommended!
9
Tremendous relief experienced
2 people found this helpful
After a bout of C-diff, my doctor recommended this probiotic. It helped enormously; I have continued taking it, and anyone with bowel issues should give it a try.
8
Gained relief
2 people found this helpful
My naturopathic doctor suggested I take S-Boulardii for my long-standing diarrhoea. He advised using it 2-3 times a day, and it effectively addressed my issue while I awaited other natural supplements. I now always keep it on hand for preventative measures as well.
9
Smooth daily movements
1 people found this helpful
These probiotics are undeniably effective. After taking them, I have daily smooth bowel movements and rarely experience diarrhoea, whereas I used to have it once or twice a week.
Frequently Asked Questions
9
Quick bowel relief
6 people found this helpful
This remedy effectively tackled bowel issues, especially post-antibiotic use, and produced results almost immediately after the first capsule. My husband's digestive troubles have significantly improved; he now asks for them whenever he feels discomfort. Highly recommended!
7.5
Stabilised bowel movements
2 people found this helpful
I originally bought this to treat candida, and after finishing that course, I continued taking it out of habit without expectations. After a month, my bowel movements stabilised! I believe this bacteria aligns well with my constitution, so I will continue to use it.
7.5
Smooth bowel movements
The advanced version of probiotics withstands antibiotics. I have felt comfortable and experienced smooth bowel movements on the first day after taking it. Continuing observation is necessary.
9
Satisfactory results
1 people found this helpful
After two years of bowel problems and trying other probiotics without success, I am now on my second bottle of these and my situation is much better. I am very pleased with this product.
9
Effective bowel regulation
1 people found this helpful
My bowel movements improve considerably when I take it; I often have a bowel movement three times a day on the days I use it. It’s extremely effective!
9
Effective for IBS
4 people found this helpful
This is the first time I've purchased this product, recommended by a friend for my irritable bowel syndrome and gastritis. My husband and I take 2 capsules daily before meals, and it has worked remarkably well. He no longer experiences sudden diarrhoea and his bowel movements are normal. I am pleased and would love to purchase again in the future. Highly recommended!
8
Consistent good bowel movements
2 people found this helpful
Unlike other antiflatulent products, I got used to this without losing its effect. It's been amazing as I've enjoyed good bowel movements for several months. Thank you!
9
Acne reduction noted
1 people found this helpful
I recommend this for anyone with irritable bowel syndrome and frequent acne. If I have something slightly spicy, I usually get diarrhoea within 30 minutes, but since using this, the inflammation and acne have lessened, and I avoid those uncomfortable bowel issues.
7.5
Less nervous travel
3 people found this helpful
My husband experienced significant improvement as a nervous traveller. I have purchased this product three times. Initially, I consumed it with only lactic acid bacteria, but my condition didn’t improve. Now, I take it consistently and have noticed substantial benefits.
8
Gained relief
2 people found this helpful
My naturopathic doctor suggested I take S-Boulardii for my long-standing diarrhoea. He advised using it 2-3 times a day, and it effectively addressed my issue while I awaited other natural supplements. I now always keep it on hand for preventative measures as well.
7.5
Daily bowel movements
8 people found this helpful
After more than 10 years of dealing with constipation and acne, I can proudly say I now have daily bowel movements since starting this product, and my breakouts have decreased. I take three tablets a day.
7
Saccharomyces boulardii aids IBS-D
We assessed how Saccharomyces boulardii CNCM I-745 affects patients with diarrhea-predominant irritable bowel syndrome (IBS-D) linked to small intestinal bacterial overgrowth (SIBO). In our study, patients received either the probiotic with dietary advice or just dietary advice for 15 days.
Those taking the probiotic showed a greater decrease in bacterial overgrowth and better improvement in digestive symptoms. Specifically, the reduction in digestive distress was more pronounced, and the friendly bacteria F. prausnitzii increased among these patients. Our findings suggest that further exploration of this promising probiotic is warranted.
Those taking the probiotic showed a greater decrease in bacterial overgrowth and better improvement in digestive symptoms. Specifically, the reduction in digestive distress was more pronounced, and the friendly bacteria F. prausnitzii increased among these patients. Our findings suggest that further exploration of this promising probiotic is warranted.
8
We explored how Saccharomyces boulardii CNCM I-745 impacts intestinal motility, particularly in the context of irritable bowel syndrome (IBS) with diarrhea. Using isolated rat ileum, we observed that S. boulardii can significantly reduce contractions induced by serotonin, suggesting it helps to regulate bowel movements.
This probiotic appears to work by inhibiting serotonin-induced contractions, providing insight into its potential effectiveness for those suffering from IBS. However, it didn’t influence contractions caused by acetylcholine, indicating a targeted action on serotonin pathways.
This probiotic appears to work by inhibiting serotonin-induced contractions, providing insight into its potential effectiveness for those suffering from IBS. However, it didn’t influence contractions caused by acetylcholine, indicating a targeted action on serotonin pathways.
0
We conducted a randomized double-blind placebo-controlled trial to understand the effects of saccharomyces boulardii on diarrhea-predominant irritable bowel syndrome (IBS). In our study, thirty-five patients received either the probiotic or a placebo for a month.
After careful evaluation of symptoms and quality of life before, during, and after treatment, we found no significant differences between the two groups. This suggests that saccharomyces boulardii didn’t provide any real benefits for patients suffering from diarrhea-predominant IBS.
After careful evaluation of symptoms and quality of life before, during, and after treatment, we found no significant differences between the two groups. This suggests that saccharomyces boulardii didn’t provide any real benefits for patients suffering from diarrhea-predominant IBS.
References
- Girard P, Verleye M, Castagné V. Serotoninergic Mechanisms of Action in the Relaxant Properties of Saccharomyces boulardii CNCM I-745 on the Intestine. Dig Dis Sci. 2025;70:191. doi:10.1007/s10620-024-08786-y
- Bustos Fernández LM, Man F, Lasa JS. Impact of Saccharomyces boulardii CNCM I-745 on Bacterial Overgrowth and Composition of Intestinal Microbiota in Diarrhea-Predominant Irritable Bowel Syndrome Patients: Results of a Randomized Pilot Study. Dig Dis. 2023;41:798. doi:10.1159/000528954
- Gu Y, Wang C, Qin X, Zhou B, Liu X, et al. Saccharomyces boulardii, a yeast probiotic, inhibits gut motility through upregulating intestinal serotonin transporter and modulating gut microbiota. Pharmacol Res. 2022;181:106291. doi:10.1016/j.phrs.2022.106291
- Constante M, De Palma G, Lu J, Jury J, Rondeau L, et al. Saccharomyces boulardii CNCM I-745 modulates the microbiota-gut-brain axis in a humanized mouse model of Irritable Bowel Syndrome. Neurogastroenterol Motil. 2021;33:e13985. doi:10.1111/nmo.13985
- Leventogiannis K, Gkolfakis P, Spithakis G, Tsatali A, Pistiki A, et al. Effect of a Preparation of Four Probiotics on Symptoms of Patients with Irritable Bowel Syndrome: Association with Intestinal Bacterial Overgrowth. Probiotics Antimicrob Proteins. 2019;11:627. doi:10.1007/s12602-018-9401-3
- Brun P, Scarpa M, Marchiori C, Sarasin G, Caputi V, et al. Saccharomyces boulardii CNCM I-745 supplementation reduces gastrointestinal dysfunction in an animal model of IBS. PLoS One. 2017;12:e0181863. doi:10.1371/journal.pone.0181863
- Abbas Z, Yakoob J, Jafri W, Ahmad Z, Azam Z, et al. Cytokine and clinical response to Saccharomyces boulardii therapy in diarrhea-dominant irritable bowel syndrome: a randomized trial. Eur J Gastroenterol Hepatol. 2014;26:630. doi:10.1097/MEG.0000000000000094
- Bafutto M, Almeida JR, Leite NV, Costa MB, Oliveira EC, et al. Treatment of diarrhea-predominant irritable bowel syndrome with mesalazine and/or Saccharomyces boulardii. Arq Gastroenterol. 2013;50:304. doi:10.1590/S0004-28032013000400012
- Kabir MA, Ishaque SM, Ali MS, Mahmuduzzaman M, Hasan M. Role of Saccharomyces boulardii in diarrhea predominant irritable bowel syndrome. Mymensingh Med J. 2011;20:397.
- Choi CH, Jo SY, Park HJ, Chang SK, Byeon JS, et al. A randomized, double-blind, placebo-controlled multicenter trial of saccharomyces boulardii in irritable bowel syndrome: effect on quality of life. J Clin Gastroenterol. 2011;45:679. doi:10.1097/MCG.0b013e318204593e
- McFarland LV. Systematic review and meta-analysis of Saccharomyces boulardii in adult patients. World J Gastroenterol. 2010;16:2202.
- Siyal M, Abbas Z, Amir MR, Qadeer MA. Saccharomyces cerevisiae for abdominal pain and discomfort in irritable bowel syndrome patients. Pak J Med Sci. 2024;40:492. doi:10.12669/pjms.40.3.8349
- Liu J, Ren H, Yuan F, Shao M, Luo H. The effects of on rat colonic hypermotility induced by repeated water avoidance stress and the potential mechanism. PeerJ. 2022;10:e14390. doi:10.7717/peerj.14390
- Mourey F, Decherf A, Jeanne JF, Clément-Ziza M, Grisoni ML, et al. I-3856 in irritable bowel syndrome with predominant constipation. World J Gastroenterol. 2022;28:2509. doi:10.3748/wjg.v28.i22.2509
- Gayathri R, Aruna T, Malar S, Shilpa B, Dhanasekar KR. Efficacy of Saccharomyces cerevisiae CNCM I-3856 as an add-on therapy for irritable bowel syndrome. Int J Colorectal Dis. 2020;35:139. doi:10.1007/s00384-019-03462-4
- Cayzeele-Decherf A, Pélerin F, Leuillet S, Douillard B, Housez B, et al. CNCM I-3856 in irritable bowel syndrome: An individual subject meta-analysis. World J Gastroenterol. 2017;23:336. doi:10.3748/wjg.v23.i2.336
- Spiller R, Pélerin F, Cayzeele Decherf A, Maudet C, Housez B, et al. Randomized double blind placebo-controlled trial of Saccharomyces cerevisiae CNCM I-3856 in irritable bowel syndrome: improvement in abdominal pain and bloating in those with predominant constipation. United European Gastroenterol J. 2016;4:353. doi:10.1177/2050640615602571
- Pineton de Chambrun G, Neut C, Chau A, Cazaubiel M, Pelerin F, et al. A randomized clinical trial of Saccharomyces cerevisiae versus placebo in the irritable bowel syndrome. Dig Liver Dis. 2015;47:119. doi:10.1016/j.dld.2014.11.007
